Background: Air pollution in large cities is one of the main difficulties that have harmful effects on humans and the environment and cause various diseases including cardiovascular disease. So, present study with aim of Estimation of Cardiovascular Death, Attributed to CO Exposure in Tehran Megacity in during a five-year period (2010-2014) by using AirQ Model were performed.

Materials and Methods: This Study was a descriptive–analytic at first, hourly data of pollutants were taken from the environmental protection agency Tehran and Air Quality Control Company and validated according to the WHO guidelines. Required statistical parameters calculated for health effect quantifying and finally processed data converted to input and requirements AirQ model data and health effects quantifying were performed using this model. The final results on deaths due to cardiovascular disease were presented in tables and graphs format.

Results: Results showed annual average concentration of CO in Tehran in 2010-2014 are 49, 31, 11,12,21,76 mg/ m3 respectively. In addition, the number of cardiovascular deaths in 2011-2015 is 52,37,29,31,42 respectively

Conclusion: According to the results, CO as well as other pollutants can adversely affect human health. Due to high levels of air pollution and its related health consequences, particularly cardiovascular disease, should take appropriate measures to reduce air pollution.